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Acceptance of afatinib in this indication was predicated on the principal endpoint of PFS from the LUX-Lung 3 medical trial where afatinib considerably delayed tumor growth in comparison with standard chemotherapy. Furthermore, afatinib may be the first treatment showing an OS advantage for patients with particular types of EGFR mutation-positive NSCLC in comparison to chemotherapy. A substantial OS advantage was demonstrated individually in the LUX-Lung 3 and 6 trials for patients with common EGFR mutation in comparison to chemotherapy.. Boehringer announces LUX-Lung 8 data that compares efficacy of afatinib, erlotinib in sufferers with advanced SCC Boehringer Ingelheim today announced overall survival outcomes from the LUX-Lung 8 trial that directly compared the efficacy and protection of two EGFR-directed remedies, erlotinib and afatinib, in individuals with advanced squamous cell carcinoma of the lung, progressing after treatment with first-collection chemotherapy.