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Finally, they discovered no difference between patients taking SSRIs and the ones taking other drugs, referred to as tricyclic antidepressants. The authors explain that, as the absolute risk of suicide is low, the widespread use of SSRIs makes this a populace health concern. In addition they warn that major restrictions in the released trials may have resulted in underestimates of the risk of suicide tries. The second study reviewed 477 trials submitted by drug companies to the safety overview of the Medications and Healthcare products Regulatory Company . These trials compared SSRIs with placebo in adults with depression and other clinical circumstances. The research team found no evidence that SSRIs increased the risk of suicide. They found weak evidence of an increased risk of self damage, but no proof an increased threat of suicidal thoughts.